However, more studies are necessary to determine their effectiveness in treating PE. Though most of these are only available by prescription, some antidepressants, such as chlorpheniramine, are available over the counter. Availability: The Food and Drug Administration (FDA) provides a list of antidepressant medications it has tested and approved.However, there are a few concerns with antidepressant use: That study showed that the SSRI drug paroxetine was the most effective drug for delaying ejaculation. However, individuals may need up to 3 weeks of treatment to achieve the maximum effect. These antidepressants are SSRIs and tricyclic antidepressants (TCAs).Īn older 2016 study shows that ejaculation delay can increase within 10 days of taking the drug. However, several studies show that the off-label use of two antidepressants may help treat PE by delaying ejaculations. The common use of antidepressant medication is to treat individuals with depression and anxiety. ![]() People taking nitrate medications, such as nitroglycerin, should try to avoid taking PDE5 inhibitors due to a risk of a sharp decline in blood pressure.Īdditionally, those looking to use off-label ED drugs, such as Viagra, must be aware of how they may interact with other medications.įor example, health experts warn that individuals should not combine the hypertension drug riociguat with ED medication.Īll the above ED medications are available via prescription. an erection that lasts longer than 4 hours.Side effects depend on the specific type of drug and may include: The overall benefits of PDE5 inhibitors are similar to those of other medications and include better ejaculation control, confidence, and delayed ejaculation. However, these medications are more effective if a person takes them in combination with selective serotonin reuptake inhibitors (SSRIs). ![]() They work by affecting the enzymes in the penis and lungs to prolong erections and decrease pressure on the lungs, which calms down breathing.Ĭurrent research suggests that PDE5 inhibitors are effective in treating PE. These are called phosphodiesterase 5 (PDE5) inhibitors and include: ![]()
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